technetium-99m labeled red blood cells-Jose Cancelas

Technetium-99m labeled red blood cells-Jose Cancelas refers to a radiopharmaceutical preparation of autologous erythrocytes labeled with the radionuclide Technetium-99m, specifically as utilized in clinical research led by Dr. Jose Cancelas at the Hoxworth Blood Center. This agent is employed as a diagnostic tracer to evaluate the recovery and long-term survival of red blood cells (RBCs) following transfusion. The labeling process involves the intracellular binding of 99mTc to the hemoglobin molecule, typically facilitated by a stannous (tin) reducing agent. In the context of Phase 1 comparative studies, it serves as a standard reference to validate novel, non-radioactive labeling techniques such as biotinylation. By measuring the radioactivity of the labeled cells in the circulation over time, researchers can determine the pharmacokinetic profile and quality of stored or processed blood products.

Other names

Technetium Tc 99m Labeled Red Blood Cells99mTc-labeled erythrocytesTechnetium 99m Labeled Red Blood CellsTechnetium99m Labeled Red Blood CellsTechnetium-99m Labeled Red Blood Cells