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Drug intelligence / Profile preview
technetium Tc 99m carbon
- Development stage
- Unknown
- Lead developer
- Cyclomedica
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Nanoparticles → Drug Delivery Systems
- Administration
- Inhalation
01
Overview
Technetium Tc 99m carbon (marketed under the brand name Technegas) is an inhaled radioactive diagnostic agent consisting of an ultrafine dispersion of technetium-99m-labeled carbon nanoparticles. It is produced by heating sodium pertechnetate Tc 99m in a graphite crucible at high temperatures (approximately 2,750°C) in a specialized generator, which volatilizes both the technetium and carbon to form hydrophobic nanoparticles with gas-like behavior. Upon inhalation, these submicron particles easily diffuse to the lung periphery and adhere to the alveolar walls. It is primarily used in single-photon emission computed tomography (SPECT) or planar imaging for the visualization of pulmonary ventilation and the evaluation of pulmonary embolism when paired with perfusion imaging.
- Brand names
- Technegas
- Other names
- nanosized graphite encapsulating technetium-99mnanosized graphite encapsulating technetium-99m metal complexestechnetium (99mTc) carbontechnetium Tc 99m-labeled carbon
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