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technetium Tc 99m H7ND
- Development stage
- Phase 2
- Lead developer
- Bayer HealthCare Pharmaceuticals
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Technetium Tc 99m H7ND is an investigational **FAP-targeted SPECT/CT diagnostic radiopharmaceutical** developed for imaging fibroblast activation protein-positive tumor lesions. The small-molecule H7ND ligand binds fibroblast activation protein alpha expressed in tumor-associated fibroblasts; its technetium-99m radiolabel emits gamma radiation that enables lesion visualization by single-photon emission computed tomography. It is being evaluated for diagnosis of peritoneal metastasis in gastrointestinal malignancies and has reached Phase 2 clinical development in China.
- Other names
- [99mTc]-H7ND99mTc-H7NDtechnetium [99mTc]-H7NDtechnetium Tc 99m H7ND
02
Targets
NeuraminidaseBB receptors (Bombesin receptor family)SSTR (Somatostatin receptors)
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