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Technetium Tc 99m-labeled silk fibroin nanoparticles is a radiolabeled polymeric nanoparticle formulation consisting of silk fibroin nanoparticles (SFN) directly labeled with the gamma-emitting radionuclide technetium-99m (Tc-99m). Developed by researchers in Spain, including the Hospital Clínico Universitario Virgen de la Arrixaca, the Instituto Murciano de Investigación Biosanitaria (IMIB)-Arrixaca, and the Instituto Murciano de Investigación y Desarrollo Agrario y Alimentario (IMIDA), this agent is designed as a diagnostic imaging probe for single-photon emission computed tomography (SPECT). It is primarily utilized in preclinical research to evaluate the in vivo biodistribution, pharmacokinetics, and stability of silk fibroin-based drug delivery systems.
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