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technetium tc 99m succimer
- Development stage
- Approved
- Lead developer
- Theragnostics
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Technetium Tc 99m succimer is a **radioactive diagnostic agent** used for imaging the renal cortex to evaluate functional renal tissue in patients with **renal parenchymal disorders**. The compound consists of technetium-99m, a gamma-emitting radioisotope, complexed with succimer (dimercaptosuccinic acid, DMSA), which selectively binds the cortical region of the kidneys. It is administered intravenously and localizes to the proximal renal tubular cells, allowing visualization via gamma scintigraphy or SPECT. The main clinical application is the assessment of renal cortical defects, scarring, and differential kidney function. Mechanistically, the tracer binds to sulfhydryl groups in the renal proximal tubules, enabling high-resolution functional imaging.
- Brand names
- NephroScanMPI DMSA
- Other names
- technetium tc 99m dimercaptosuccinic acidtechnetium tc-99m-dmsatechnetium-99m succimertechnetium99m succimertechnetium 99m succimertechnetium-99m dimercaptosuccinic acidtechnetium99m dimercaptosuccinic acidtechnetium 99m dimercaptosuccinic acidtechnetium tc99m succimertechnetium tc-99m-succimer
02
Targets
GSTA1 (Glutathione S-transferase A1)
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