Drug intelligence / Profile preview

tecoma stans

Development stage
Phase 3
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Tecoma stans, also known as yellow bells or yellow trumpet bush, is a flowering perennial shrub in the Bignoniaceae family. It is widely recognized for its diverse pharmacological properties and has been traditionally used in Mexico, Central America, and the Caribbean for the management of type 2 diabetes, renal disorders, and gastrointestinal issues. Scientific investigations have demonstrated that Tecoma stans extracts possess hypoglycemic, anti-inflammatory, antioxidant, and antimetastatic activities. Its therapeutic effects are attributed to a variety of bioactive secondary metabolites, including phenylethanoid glycosides (such as verbascoside and isoverbascoside) and flavonoids (such as luteolin and apigenin). Clinical research has specifically evaluated its efficacy as part of an herbal mixture in improving metabolic profiles in diabetic patients. Additionally, its bioactive components have shown potential in inhibiting pro-inflammatory cytokines and markers of oxidative stress in arthritic models.

Other names
yellow bellsyellow trumpet bushTecoma stans (L.) Juss. ex KunthT. stansEsperanza
02

Targets

BCL-2 (BCL-2 family)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)VEGFR2 (Vascular endothelial growth factor receptor 2)TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)IL1B (Interleukin-1 beta)

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