tedolidine

Tedolidine (also known as NH160030 or NH130) is a novel small molecule analgesic developed by Jiangsu Nhwa Pharmaceutical. It acts as a **μ-opioid receptor (MOR) agonist**, specifically designed as a biased agonist to provide effective pain relief with a potentially improved safety profile, such as reduced respiratory depression and gastrointestinal side effects, compared to traditional opioids. Tedolidine is currently in clinical development for the management of **postoperative pain**. It is typically administered as a fumarate salt via intravenous injection, often through patient-controlled intravenous analgesia (PCIA) systems. Clinical trials have evaluated its efficacy in various surgical settings, including multimodal analgesia regimens for patients undergoing thoracoscopic esophagectomy.

Other names

tedolidine fumarate特多利定