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tegafur-uracil + vinorelbine
- Development stage
- Unknown
- Lead developer
- Taiho Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
tegafur-uracil + vinorelbine is a chemotherapy combination used primarily in the treatment of advanced non-small cell lung cancer (NSCLC). Tegafur-uracil (UFT) is an oral anticancer agent composed of tegafur, a prodrug of 5-fluorouracil (5-FU), and uracil, which inhibits dihydropyrimidine dehydrogenase to prolong the activity of 5-FU. Vinorelbine is an intravenous antimitotic agent that disrupts microtubule dynamics, leading to mitotic arrest and cell death. The combination has shown synergistic activity in experimental models and has been evaluated in clinical trials for efficacy and safety[1][2][3].
- Other names
- tegafur-uracil and vinorelbineUFT and vinorelbine
02
Targets
TS (Thymidylate synthase)TUBB (Tubulin (alpha and beta subunits))DPYD (Dihydropyrimidine dehydrogenase)
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