Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
tegilildine fumarate
- Development stage
- Unknown
- Lead developer
- Haisco Pharmaceutical Group
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Tegilildine fumarate (HSK21542) is a potent and highly selective peripherally acting **kappa opioid receptor (KOR) agonist** developed by Haisco Pharmaceutical Group. It is designed to provide analgesic and antipruritic effects while minimizing central nervous system (CNS) side effects, such as sedation, respiratory depression, and dysphoria, which are commonly associated with mu-opioid receptor agonists or centrally acting KOR agonists. The drug is primarily being investigated for the management of postoperative pain and chronic kidney disease-associated pruritus (CKD-aP). In clinical trials, it has demonstrated significant efficacy in reducing pain intensity following elective surgeries and improving pruritus scores in patients undergoing hemodialysis.
- Other names
- tegilildineHSK21542 fumarateHSK-21542 fumarateHSK 21542 fumarate
02
Targets
KOR (Kappa opioid receptor)CNR1 (Cannabinoid receptor 1)
Beyond the preview
Go deeper on tegilildine fumarate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on tegilildine fumarate.