Drug intelligence / Profile preview

telmisartan + amlodipine + chlorthalidone

Development stage
Phase 3
Lead developer
Yuhan
Modality
Small Molecules
Administration
Oral
01

Overview

Telmisartan + amlodipine + chlorthalidone is an oral fixed-dose triple antihypertensive combination used for **essential hypertension**. It combines telmisartan, an angiotensin II type 1 receptor blocker; amlodipine, a dihydropyridine L-type calcium-channel blocker; and chlorthalidone, a thiazide-like diuretic that inhibits renal sodium-chloride reabsorption. The Yuhan-developed product was studied as YH22162 and is marketed in South Korea as Truset in multiple strengths, including 40/5/12.5 mg, 80/5/12.5 mg, and 80/5/25 mg. Clinical studies have evaluated both conventional-dose and low-dose versions of this triple combination in essential hypertension. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02620163))

Brand names
TelamcloTruset
Other names
TEL/AML/CTDamlodipine + chlorthalidone + telmisartantelmisartan + amlodipine + chlorthalidonetelmisartan/amlodipine/chlorthalidone
02

Targets

LTCC (Voltage-gated calcium channel (L-type))PPARG (Peroxisome proliferator-activated receptor gamma)AGTR1 (Angiotensin II Type-1 receptor)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

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