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Telomir-Zn is an oral small molecule therapeutic developed by Telomir Pharmaceuticals, representing the formulated version of the lead candidate Telomir-1 (also known as Zn-Telomir). It functions by modulating intracellular metal homeostasis, specifically reducing labile redox-active iron and copper while increasing the availability of bioavailable zinc. This metal modulation targets epigenetic enzymes within the lysine demethylase (KDM) families, which are critical regulators of oxidative stress, DNA methylation, and genomic stability. Preclinical research has demonstrated its potential in treating various cancers—including triple-negative breast cancer, prostate cancer, pancreatic cancer, and leukemia—as well as addressing aging and degenerative diseases. Unlike traditional cytotoxic agents, Telomir-Zn exerts its effects through iron-dependent pathways and the regulation of histone and DNA methylation.
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