Drug intelligence / Profile preview

Telostop Plus

Development stage
Phase 3
Lead developer
Ildong Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Telostop Plus is an oral fixed-dose combination tablet containing the small-molecule agents telmisartan, amlodipine, and rosuvastatin, developed by Ildong Pharmaceutical for the concurrent treatment of hypertension and hyperlipidemia.[2][4][7][11] Telmisartan is an angiotensin II type 1 receptor blocker that reduces vasoconstriction and aldosterone-mediated volume expansion, lowering blood pressure and cardiovascular risk.[1][3][7] Amlodipine is a dihydropyridine calcium channel antagonist that inhibits L-type calcium influx in vascular smooth muscle, producing vasodilation and additional blood pressure reduction.[7] Rosuvastatin is an HMG‑CoA reductase inhibitor that decreases hepatic cholesterol synthesis, upregulates LDL receptors, and lowers LDL cholesterol and other atherogenic lipids, thereby improving dyslipidemia and cardiovascular risk profiles.[7] Telostop Plus is marketed in South Korea in multiple telmisartan/amlodipine/rosuvastatin dose strengths for patients with coexisting hypertension and dyslipidemia, and has been studied in post-marketing surveillance for safety and efficacy in these indications.[2][4][7][10][11][14]

Brand names
Telostop Plus
Other names
Amlodipine/rosuvastatin/telmisartan - Ildong PharmaceuticalAmlodipine/telmisartan/rosuvastatin - Ildong PharmaceuticalRosuvastatin/telmisartan/amlodipine - Ildong PharmaceuticalTAR - Ildong PharmaceuticalID-TARTelmisartan/amlodipine/rosuvastatin - Ildong Pharmaceutical
02

Targets

AGTR1 (Angiotensin II Type-1 receptor)PPARG (Peroxisome proliferator-activated receptor gamma)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)LTCC (Voltage-gated calcium channel (L-type))

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