Drug intelligence / Profile preview

temazepam

Development stage
Approved
Lead developer
Mallinckrodt
Modality
Small Molecules
Administration
Oral
01

Overview

Temazepam is a benzodiazepine used primarily for the short-term treatment of insomnia, including difficulty falling asleep and staying asleep. It acts by enhancing the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, at the GABA-A receptor in the brain. This results in sedative, anxiolytic, muscle relaxant, and anticonvulsant effects. Temazepam is typically administered orally as a capsule and is intended for use over brief periods (generally 7–10 days) due to risks of dependence and tolerance. It may also be used as premedication before surgical or dental procedures to induce relaxation.

Brand names
Restoril
Other names
temazepam7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
02

Targets

GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)GABRA2 (Gamma-aminobutyric acid receptor subunit alpha 2)GABRA3 (Gamma-aminobutyric acid receptor subunit alpha-3)GABRA5 (Gamma-aminobutyric acid type A receptor subunit alpha-5)

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