Drug intelligence / Profile preview

Tenagril

Development stage
Unknown
Lead developer
3Sixty Biomedicine
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Tenagril is a natural, complementary and alternative medicine (CAM) supplement developed by 3Sixty Biomedicine for the prevention and relief of migraine symptoms. The primary active ingredient in Tenagril is a standardized extract of *Tanacetum parthenium* (Feverfew), which contains parthenolide as its key bioactive compound. Feverfew is traditionally used for its anti-inflammatory and vasodilatory properties. Tenagril is believed to work by inhibiting the release of serotonin and reducing the synthesis of inflammatory prostaglandins, thereby addressing the neurovascular dysregulation and blood vessel dilation associated with migraine pathology. It is marketed as a daily prophylactic capsule to reduce the frequency and severity of migraine attacks, as well as associated symptoms like nausea and vomiting.

Brand names
Tenagril
Other names
feverfew extracttanacetum parthenium extract
02

Targets

IKBKB (IKKβ)RELA (Nuclear Factor Kappa B Subunit p65)

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