tenascin-C shRNA1 lentivirus

TNC shRNA1 lentivirus is an experimental gene therapy agent designed to silence the expression of tenascin-C (TNC), a prominent extracellular matrix protein in the glioblastoma (GBM) microenvironment. It consists of a short hairpin RNA (shRNA) sequence targeting TNC mRNA, delivered via a lentiviral vector. By reducing TNC levels, the agent is used to investigate the go-or-grow phenotypic switch in glioma, where TNC typically promotes cell invasion at the expense of proliferation. Research using this construct in patient-derived GBM neurospheres and intracranial xenografts has shown that TNC knockdown decreases tumor invasion, increases tumor proliferation, and enhances sensitivity to anti-proliferative treatments. Additionally, it modulates the behavior of stromal cells such as endothelial cells and microglia within the tumor microenvironment.

Other names

tenascin-C shRNA1 lentivirusshTNC lentivirus