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Tendu
- Development stage
- Phase 1
- Lead developer
- Ultimovacs
- Modality
- Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Peptides
- Administration
- Intradermal
01
Overview
TENDU is a therapeutic peptide cancer vaccine developed using the tetanus-epitope targeting (TET) platform. It is designed to stimulate and enhance T cell responses against tumor-associated antigens by combining cancer-specific peptides with a vaccine adjuvant in a single conjugated molecule. The platform leverages pre-existing immunity from standard tetanus vaccinations to boost anti-tumor immune responses. TENDU is being investigated as an immunostimulant for patients with prostate cancer who have relapsed after radical prostatectomy. The first-in-human Phase I clinical trial evaluates its safety, tolerability, and ability to activate immune responses prior to standard-of-care treatments such as radiation and antihormone therapy.
- Other names
- TENDU vaccine
02
Targets
MHC II (Major histocompatibility complex class II receptor)TCR (T cell antigen receptor complex)MAGEA8 (Melanoma-associated antigen 8)
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