Drug intelligence / Profile preview

TENGPURE-M

Development stage
Phase 4
Lead developer
Acinom Healthcare
Modality
Small Molecules
Administration
Oral
01

Overview

TENGPURE-M is a fixed-dose combination pharmaceutical product developed by Acinom Healthcare for the treatment of type 2 diabetes mellitus. It contains two active small molecule ingredients: teneligliptin and metformin. Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by preventing the degradation of incretin hormones such as glucagon-like peptide-1 (GLP-1), which in turn stimulates insulin secretion and inhibits glucagon release in a glucose-dependent manner. Metformin, a biguanide, complements this action by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity via the activation of AMP-activated protein kinase (AMPK). As a generic formulation, TENGPURE-M provides a cost-effective option for dual-therapy management of hyperglycemia.

Brand names
TENGPURE-MTENGPURE-M500TENGPURE-M-500TENGPURE-M 500
Other names
Teneligliptin and Metformin Hydrochloride Tablets
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)DPP-4 (Dipeptidyl Peptidase-IV)ND1 (Mitochondrial electron transport chain complex I)

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