tenitramine

Tenitramine is a small molecule organic nitrate that functions as a nitrovasodilator in cardiac therapy. It is primarily indicated as an antianginal agent for the treatment and prevention of angina pectoris. The drug acts as a nitric oxide donor; upon administration, it releases nitric oxide (NO), which activates soluble guanylate cyclase. This activation leads to increased levels of cyclic guanosine monophosphate (cGMP), resulting in the relaxation of vascular smooth muscle and subsequent vasodilation. This process reduces both cardiac preload and afterload, thereby decreasing myocardial oxygen demand and improving coronary blood flow. Tenitramine is categorized under the ATC code C01DA38 and has been historically marketed under the brand name Tinitran.

Brand names

Tinitran

Other names

TenitramineN,N,N',N'-tetrakis(2-nitroxyethyl)ethylenediamineTenitraminumTEEDN