Drug intelligence / Profile preview

tenofovir + emtricitabine + zidovudine + abacavir

Development stage
Unknown
Lead developer
Gilead Sciences
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination of four antiretroviral medications used in HIV treatment. The combination includes: - **Tenofovir disoproxil fumarate (TDF)**: A nucleotide reverse transcriptase inhibitor (NtRTI) - **Emtricitabine (FTC)**: A nucleoside reverse transcriptase inhibitor (NRTI) - **Zidovudine (ZDV)**: A nucleoside reverse transcriptase inhibitor (NRTI) - **Abacavir (ABC)**: A nucleoside reverse transcriptase inhibitor (NRTI) These medications work by inhibiting HIV reverse transcriptase, preventing viral replication. Each component has distinct adverse effect profiles: tenofovir primarily affects renal function and bone density, zidovudine causes hematological effects and lipoatrophy, abacavir can cause hypersensitivity reactions and potential cardiovascular effects, while emtricitabine has a relatively favorable safety profile.

02

Targets

Human immunodeficiency virus type 1 reverse transcriptase

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