tenofovir disoproxil aspartate

Tenofovir disoproxil aspartate is a **prodrug** form of tenofovir, designed to enhance oral bioavailability and membrane permeability. Tenofovir, once liberated from the prodrug in vivo, is phosphorylated to its active diphosphate form inside cells. The active metabolite is a **nucleotide analog reverse transcriptase inhibitor (NtRTI)**, acting by direct inhibition of HIV-1 reverse transcriptase and hepatitis B polymerase. This is accomplished through competition with deoxyadenosine 5’-triphosphate and subsequent chain termination during viral DNA synthesis, thereby blocking viral replication[1][2][3][4]. Like other tenofovir prodrugs, it is generally used for the treatment of **HIV-1 infection** and **chronic hepatitis B**, though the specific aspartate salt may represent a formulation variant.

Brand names

tenofovir disoproxil aspartate

Other names

tenofovir disoproxil aspartate