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tenofovir disoproxil fumarate + emtricitabine + cabotegravir long-acting

Development stage
Preclinical
Lead developer
ViiV Healthcare
Modality
Small Molecules
Administration
Oral, Intramuscular
01

Overview

This is a combination regimen consisting of three antiretroviral agents used for the prevention and/or treatment of HIV-1 infection. Tenofovir disoproxil fumarate and emtricitabine are both nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) that inhibit HIV reverse transcriptase, thereby blocking viral replication[2][7][8]. Cabotegravir long-acting is an integrase strand transfer inhibitor (INSTI) formulated for extended-release injectable administration, which blocks the integration of viral DNA into the host genome[6]. This combination leverages two oral NRTIs with a long-acting injectable INSTI to provide potent suppression or prevention of HIV infection. The regimen may be considered in research or clinical settings where both daily oral PrEP/ART and long-acting injectable options are being evaluated or used.

Other names
cabotegravir + tenofovir + emtricitabine
02

Targets

Human immunodeficiency virus type 1 reverse transcriptaseIntegrase allosteric pocket (HIV)

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