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tenofovir disoproxil orotate
- Development stage
- Phase 3
- Lead developer
- Dong-A ST
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tenofovir disoproxil orotate (DA-2802) is an oral small molecule nucleotide reverse transcriptase inhibitor developed for the treatment of chronic hepatitis B. It is a novel salt form of tenofovir prodrug, similar in mechanism to tenofovir disoproxil fumarate (TDF), and works by inhibiting hepatitis B virus (HBV) replication through chain termination during viral DNA synthesis. Clinical trials have demonstrated that DA-2802 is non-inferior to TDF in reducing HBV DNA levels and has a comparable safety profile, with most adverse events being mild to moderate. The drug was developed by Dong-A ST and has completed phase III clinical trials in South Korea for chronic hepatitis B[1][2][3][4][5].
- Other names
- tenofovir disoproxil orotateDA 2802DA2802DA-2802
02
Targets
Human immunodeficiency virus type 1 reverse transcriptaseHBV Pol (Hepatitis B virus polymerase)POLA1 (DNA polymerase alpha)
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