tenoxicam

Tenoxicam is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class, used primarily for its anti-inflammatory, analgesic, and antipyretic properties. It is indicated for the treatment of mild to moderate pain and the signs and symptoms associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, periarthritis of shoulders or hips, gouty arthritis, sciatica, back pain, painful periods (dysmenorrhea), and postoperative pain[1][2][4][5][6][7]. The mechanism of action involves inhibition of cyclooxygenase enzymes (COX), specifically prostaglandin G/H synthase 1 and 2 (COX‑1 and COX‑2), leading to decreased synthesis of prostaglandins that mediate inflammation and sensitize pain receptors[1][6]. This results in reduced inflammation as well as peripheral analgesia. Antipyretic effects are thought to occur via central action on the hypothalamus[1]. Tenoxicam has a long duration of action allowing once-daily dosing[5], high protein binding (~99%)[4], rapid oral absorption with complete bioavailability[1], and an elimination half-life ranging from approximately 30–140 hours[4]. It was developed by Roche.

Brand names

MobiflexTilatilTilcitinAlganexTilcotil

Other names

TénoxicamTenoxicamum