teprotide

Teprotide is a nonapeptide originally isolated from the venom of the Brazilian pit viper, *Bothrops jararaca*. It functions as an angiotensin-converting enzyme (ACE) inhibitor, blocking the conversion of angiotensin I to angiotensin II and potentiating the pharmacological actions of bradykinin. Although it demonstrated significant antihypertensive effects, its clinical utility was limited due to its peptide nature, requiring parenteral administration, its expense, and lack of oral activity. Teprotide played a crucial role as a lead compound in the rational design and development of the first orally active ACE inhibitors, such as captopril.

Other names

TepromideTeprotidumteprotidaNonapeptide-Converting Enzyme InhibitorEnzyme Inhibitor, Nonapeptide-ConvertingNonapeptide Converting Enzyme InhibitorL-pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline