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terbinafine + fluconazole
- Development stage
- Preclinical
- Lead developer
- Chattogram Medical College
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
terbinafine + fluconazole is an investigational oral antifungal combination regimen being evaluated for the treatment of refractory dermatophytosis (fungal skin infections such as tinea corporis and tinea cruris). The combination consists of two small-molecule antifungal agents with complementary mechanisms of action targeting the fungal ergosterol biosynthesis pathway. Terbinafine is an allylamine antifungal that inhibits squalene epoxidase, preventing the conversion of squalene to lanosterol, while fluconazole is a triazole antifungal that inhibits lanosterol 14-alpha-demethylase (CYP51). By targeting different steps of the same biosynthetic pathway, the combination aims to achieve synergistic fungicidal activity and overcome treatment resistance. The regimen is being evaluated in clinical trials sponsored by Chittagong Medical College.
- Other names
- fluconazole + terbinafineterbinafine and fluconazoleterbinafine/fluconazole
02
Targets
CYP51A1 (Sterol 14α-demethylase)SQLE (Squalene monooxygenase)
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