terbinafine + ketoconazole

Terbinafine + ketoconazole is a combination of two antifungal agents used primarily in topical formulations to treat a variety of fungal skin infections such as athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris), onychomycosis, and cutaneous candidiasis. This combination is particularly considered for cases that have not responded to monotherapy with either agent alone[1][5]. Terbinafine is an allylamine antifungal that inhibits squalene epoxidase, leading to ergosterol depletion and accumulation of toxic squalene within fungal cells. Ketoconazole is an azole antifungal that inhibits lanosterol 14α-demethylase, another key enzyme in the ergosterol biosynthesis pathway. The dual inhibition results in synergistic or additive effects against certain resistant or refractory fungal pathogens by disrupting different steps in the production of ergosterol—a critical component of fungal cell membranes[3][5]. This approach has shown promise especially for difficult-to-treat infections such as those caused by Aspergillus species with high minimum inhibitory concentrations (MICs) to terbinafine[5].

Brand names

Lamisil Advanced + NizoralLamisil AT + NizoralTerbinex + Nizoral

Other names

terbinafine hydrochloride + ketoconazoleterbinafine HCl + ketoconazole