Drug intelligence / Profile preview

terbutaline + theophylline

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Terbutaline + theophylline is an oral combination drug used primarily for the management of respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), bronchitis, emphysema, and bronchospasms. Terbutaline is a selective beta-2 adrenergic receptor agonist that relaxes bronchial smooth muscle to produce bronchodilation. Theophylline is a methylxanthine derivative that acts as a non-selective phosphodiesterase inhibitor and adenosine receptor antagonist; it increases intracellular cyclic AMP levels leading to bronchodilation and has mild anti-inflammatory effects. The combination provides additive or synergistic improvement in lung function compared to monotherapy with either agent alone[1][2][4]. It helps relieve symptoms such as coughing, wheezing, chest tightness, and shortness of breath[4]. Common side effects include nausea, vomiting, tremors, palpitations, increased heart rate, restlessness or nervousness[3][4].

Brand names
TergilNew AstheliteNew Asthelite Forte
Other names
theophylline + terbutaline
02

Targets

ADORA2A (Adenosine A₂A Receptor)PIK3CD (Phosphatidylinositol 3-kinase delta)PDE3ADRB2 (β2)ADORA2B (Adenosine A2B receptor)ADORA1 (Adenosine receptor A1 subtype)ADRB3 (β3)ADRB1 (β1)PDE4 (Phosphodiesterase 4A1)

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