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terguride
- Development stage
- Phase 2
- Lead developer
- ErgoNex Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Terguride is a synthetic ergoline derivative and small molecule drug that acts as a partial agonist at dopamine D2 receptor and an antagonist at serotonin 5-HT2A receptor and serotonin 5-HT2B receptor. It also exhibits activity at other serotonergic, dopaminergic, and adrenergic receptors. Terguride inhibits pituitary prolactin secretion by stimulating dopamine D2 receptors in the pituitary gland, making it effective for the treatment of hyperprolactinemia. It has also been investigated for use in pulmonary arterial hypertension (PAH), systemic sclerosis, Parkinson's disease, schizophrenia, fibromyalgia, and fibrosis. The drug was originally developed by Bayer HealthCare Pharmaceuticals and has received full marketing authorization in Japan for hyperprolactinemia; development for other indications such as PAH has been discontinued or terminated outside Japan[1][3][6][7].
- Brand names
- Dironyl
- Other names
- tergurideDironyl
02
Targets
DRD2 (Dopamine D2 Receptor)HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR2C (5-hydroxytryptamine 2C receptor)
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