terizidone

Terizidone is a broad-spectrum antibiotic used primarily as a second-line agent for the treatment of tuberculosis, especially multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). It is effective against both pulmonary and extrapulmonary forms of the disease. Chemically, terizidone is a condensation product of two D-cycloserine molecules linked by terephthalaldehyde. In vivo, it acts as a prodrug that hydrolyzes to release cycloserine. The active metabolite inhibits bacterial cell wall synthesis by competitively blocking enzymes involved in peptidoglycan formation—specifically alanine racemase and D-alanyl-D-alanine synthetase—thereby disrupting cell wall biosynthesis in *Mycobacterium tuberculosis*. It is generally bacteriostatic at clinically recommended doses and has been used in combination regimens for drug-resistant TB[1][4][6][7].

Brand names

Terizidone

Other names

TerizidonaTerizidonumTerizidone [INN]