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Terminalia arjuna bark extract
- Development stage
- Unknown
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Topical
01
Overview
Terminalia arjuna bark extract is a botanical extract derived from the stem bark of the *Terminalia arjuna* tree, a staple of Ayurvedic medicine. It is primarily utilized for its cardioprotective properties in conditions such as chronic heart failure, angina pectoris, hypertension, and dyslipidemia. The extract is a complex mixture of bioactive phytochemicals, including triterpenoids (arjunic acid, arjunetin, arjungenin), flavonoids, polyphenols, tannins, and glycosides. Its pharmacological profile is multi-targeted, exhibiting inotropic, anti-ischemic, antioxidant, antiplatelet, and hypolipidemic effects. While not developed by a single pharmaceutical entity, it has been extensively studied in clinical trials by various research institutions, particularly in the Indian subcontinent.
- Brand names
- Arjuna CapsulesArjun Terminalia Arjuna CapsulesArjun Terminalia Arjuna Powder
- Other names
- Arjuna bark extractTerminalia arjuna extractArjuna
02
Targets
CYP2D6 (Cytochrome P450 2D6)AKR1C2 (Aldo-keto reductase family 1 member C2)CYP3A4 (Cytochrome P450 3A4)
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