Drug intelligence / Profile preview

terminalia chebula

Development stage
Phase 3
Administration
Oral, Topical
01

Overview

Terminalia chebula is a plant species whose dried fruit is widely used in traditional medicine systems such as Ayurveda, Unani, Tibetan, and Siddha, often referred to as “Haritaki” or “King of Medicine”. It is prized for its **antioxidant, anti-inflammatory, antimicrobial, antidiabetic, and neuroprotective effects**, with traditional indications including constipation, digestive complaints, liver health, aging, diabetes, high cholesterol, and neurological conditions such as mild cognitive impairment. Modern studies confirm a broad range of pharmacological activities, including inhibition of acetylcholinesterase and butyrylcholinesterase, scavenging free radicals, reducing inflammation, modulating apoptosis, and antagonism of NMDA receptors. The main active constituents are chebulagic acid, chebulinic acid, chebulaginic acid, gallic acid, ellagic acid, and tannins, which contribute to its biological effects. Terminalia chebula is typically consumed orally as powder, extract, or decoction, and has a strong ethnomedical history but is not recognized as a pharmaceutical drug in modern regulatory frameworks[1][2][3][4][5][7].

Brand names
haritakimyrobalan
Other names
haritakimyrobalanchebulic myrobalanharadabala haradeabhaya
02

Targets

AcetylcholinesteraseButyrylcholinesterasePTGS2 (Prostaglandin-Endoperoxide Synthase 2)NMDAR (Glutamate receptor ionotropic, NMDA)

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