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terpene-enriched cannabis oil
- Development stage
- Phase 2
- Lead developer
- Bazelet Pharma
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Sublingual
01
Overview
Terpene-enriched cannabis oil is an investigational medical cannabis formulation developed by Bazelet to address the loss of volatile terpenes that occurs during standard extraction processes. Standard cannabis extraction often depletes up to 90% of the plant's natural monoterpenes and monoterpenoids, potentially reducing the therapeutic efficacy of the resulting oil compared to inhaled inflorescences (the 'entourage effect'). By re-introducing specifically selected terpenes into the cannabinoid-standardized oil, this formulation aims to restore or enhance the synergistic therapeutic effects of the plant. It is being evaluated in clinical trials for the management of chronic pain and acute radicular pain, where it has demonstrated potential opioid-sparing effects.
- Other names
- terpene-enriched cannabis extractterpene-enriched medical cannabis oil
02
Targets
CNR1 (Cannabinoid receptor 1)PPAR (PPAR family)TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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