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terpene-enriched CBD-dominant oil

Development stage: Unknown
Lead developer: Bazelet Nehushtan
Modality: Small Molecules
Administration: Oral

Overview

Terpene-enriched CBD-dominant oil is a specialized cannabis-based therapeutic formulation developed by Bazelet Nehushtan for the treatment of Autism Spectrum Disorder (ASD). The product consists of a high-CBD cannabis oil enriched with a specific profile of terpenes, designed to optimize the entourage effect and improve therapeutic outcomes compared to purified CBD. It is intended to modulate the endocannabinoid system and other neurotransmitter pathways to alleviate symptoms such as anxiety, aggression, and social communication deficits. The formulation has completed a pilot crossover study and is currently in Phase 2 clinical development (NCT07199218).

Other names: Terpene-enriched CBD oilASD pilot crossover study

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)CNR2 (Cannabinoid receptor type 2)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPA1 (Transient receptor potential cation channel subfamily A member 1)

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