Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
terriec acid
- Development stage
- Preclinical
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
01
Overview
Terreic acid is a naturally occurring metabolite produced by the fungus Aspergillus terreus. It is a quinone epoxide with notable antibiotic properties and functions as a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA), which catalyzes an essential step in peptidoglycan synthesis. Terreic acid inactivates MurA by covalently binding to Cys115 in the enzyme's active site. Additionally, it acts as an inhibitor of Bruton's tyrosine kinase (BTK), interfering with B-cell and mast cell activation by blocking BTK catalytic activity and its interaction with protein kinase C beta type (PKCβII). Terreic acid has demonstrated antibacterial and anticancer activities in vitro[1][3][4][7][9].
- Other names
- 2-hydroxy-3-methyl-1,4-benzoquinone 5,6-epoxide5,6-epoxy-3-hydroxy-p-toluquinone(-)-terreic acid
02
Targets
BTK (Bruton tyrosine kinase)MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase)
Beyond the preview
Go deeper on terriec acid.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on terriec acid.