Drug intelligence / Profile preview

Tesalin N

Development stage
Phase 2
Lead developer
Max Zeller Söhne
Modality
Small Molecules
Administration
Oral
01

Overview

Tesalin N is a phytopharmaceutical herbal medicinal product developed and manufactured by Max Zeller Söhne AG (Zeller Medical AG). The active ingredient is Ze 339, a standardized CO2 extract derived from the leaves of *Petasites hybridus* (butterbur), which is standardized to contain 8 mg of petasins per tablet. The product is indicated for the treatment of intermittent (seasonal) allergic rhinitis (hay fever) and associated symptoms affecting the eyes, nose, and throat. Tesalin N exhibits anti-allergic and anti-inflammatory properties by inhibiting the synthesis of leukotrienes and the release of inflammatory mediators. It was first approved in Switzerland in 2003 and transitioned from prescription to non-prescription (OTC) status in 2018.

Brand names
Tesalin NTesalin
Other names
Petasites hybridus leaf extractButterbur leaf extract
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ALOX12 (Arachidonate 12-lipoxygenase, 12S type)LTC4S (Leukotriene C4 synthase)LTA4H (Leukotriene A4 hydrolase)

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