testosterone + estradiol (Assistance publique - Hôpitaux de Paris)

Testosterone + estradiol (oestrogenes) is a combination hormonal therapy regimen used for gender-affirming care in adolescents with gender dysphoria. In the context of the TRANSADO trial (NCT06351501) sponsored by Assistance Publique - Hôpitaux de Paris, this treatment involves the administration of testosterone (typically as a transdermal gel) to transmasculine individuals and estradiol (typically topical) to transfeminine individuals. The therapy aims to induce physical changes consistent with the individual's gender identity by activating androgen receptors or estrogen receptors, respectively. The Phase 3 study evaluates the impact of early initiation (age 14) versus standard initiation (age 16) on global functioning and quality of life.

Brand names

AndrogelEstrevaProvames

Other names

testosterone + oestrogenescross-sex hormone therapygender-affirming hormone therapytestosterone transdermal gel + estradiol topical