testosterone transdermal gel

Testosterone transdermal gel is a topical androgenic formulation designed for systemic delivery of testosterone to treat male hypogonadism. Developed by Laboratorios Leon Farma S.A. (often in collaboration with partners like Ferring Pharmaceuticals for the 2% formulation), this gel is applied to the skin, where the active ingredient is absorbed into the stratum corneum and gradually released into the systemic circulation. Its mechanism of action involves the binding of testosterone to the androgen receptor (AR). Upon binding, the AR translocates to the cell nucleus, where it acts as a transcription factor to regulate the expression of genes involved in the development and maintenance of male secondary sexual characteristics, bone density, and muscle mass. This delivery method avoids the first-pass hepatic metabolism associated with oral testosterone and provides more stable serum concentrations compared to periodic intramuscular injections. Specific formulations, such as the 2% gel developed by Leon Farma, utilize specialized applicators to minimize the risk of secondary transfer to others.

Brand names

TestavanAndroGelTestimVogelxoFortestaTostranGelnateItnogen

Other names

testosterone 1% geltestosterone 1.62% geltestosterone 2% gel