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tetanus peptide melanoma vaccine

Development stage: Unknown
Lead developer: University of Virginia
Modality: Peptide-based Cancer Vaccines → Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration: Intradermal, Subcutaneous

Overview

The tetanus peptide melanoma vaccine is a cancer vaccine consisting of peptides derived from melanoma-associated antigens combined with a modified T-cell epitope derived from tetanus toxoid. It is designed to stimulate both helper T lymphocytes (HTL) and cytotoxic T lymphocytes (CTL) to generate an immune response against melanoma. The vaccine is administered as a water-in-oil emulsion, typically with an adjuvant such as Montanide ISA-51 and GM-CSF to enhance immune response.

Targets

MHC II (Major histocompatibility complex class II receptor)TCR-TT-MHCII (T cell receptor recognizing tetanus toxoid peptide-MHC class II complex)

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