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tetracaine HCl + oxymetazoline HCl
- Development stage
- Approved
- Lead developer
- St. Renatus
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Intranasal
01
Overview
This drug is a fixed-dose combination of two active ingredients delivered as an intranasal spray. Tetracaine HCl is an ester local anesthetic that blocks sodium channels on nerve membranes, inhibiting nerve impulse conduction and producing regional anesthesia. Oxymetazoline HCl is a direct-acting alpha-adrenergic agonist (vasoconstrictor) that constricts blood vessels in the nasal mucosa, reducing local blood flow and prolonging the anesthetic effect of tetracaine by limiting its systemic absorption. The combination is indicated for regional anesthesia during restorative dental procedures on maxillary teeth (Teeth 4–13 and A–J) in adults and children weighing at least 40 kg. It is administered as a nasal spray ipsilateral to the tooth being treated[1][2][3][7].
- Brand names
- Kovanaze
- Other names
- tetracaine-oxymetazoline intranasaltetracaine/oxymetazoline nasal spray
02
Targets
ADRA1A (α1A)ADRA2A (α2A)NaV (Voltage-gated sodium channels)
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