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tetradecylthioacetic acid
- Development stage
- Phase 2
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tetradecylthioacetic acid (TTA) is a synthetic 3-thia fatty acid analogue that functions as a pan-agonist of Peroxisome Proliferator-Activated Receptors (PPARs). It exhibits pronounced selectivity for PPARα, and also activates PPARδ (beta/delta) and, to a lesser extent, PPARγ. This chemical modification prevents TTA from undergoing complete β-oxidation, enhancing its biological activity. TTA modulates lipid and fatty acid metabolism by transcriptionally regulating genes involved in fatty acid uptake, transport, and mitochondrial β-oxidation. This action leads to reduced plasma lipids and anti-inflammatory effects. TTA has been investigated for its potential in metabolic disorders such as dyslipidemia, obesity, insulin resistance, type 2 diabetes, and inflammatory conditions. It is also marketed as a nutritional supplement.
- Other names
- 1-(Carboxymethylthio)tetradecane
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)PPARA (Peroxisome proliferator-activated receptor alpha)PPARD (Peroxisome proliferator–activated receptor delta)
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