Drug intelligence / Profile preview

tetrahydrocannabinol distillate

Development stage
Unknown
Lead developer
Clear Cannabis
Modality
Small Molecules
Administration
Oral, Inhalation, Sublingual, Topical
01

Overview

Tetrahydrocannabinol (THC) distillate is a highly refined cannabis extract that has undergone a molecular distillation process to isolate Delta-9-tetrahydrocannabinol from other plant compounds, including terpenes, flavonoids, and other cannabinoids. The production process typically involves initial extraction (e.g., using CO2 or ethanol), winterization to remove lipids and waxes, and fractional distillation under vacuum to achieve high purity, often exceeding 90% THC content. Because the distillation process involves heat, the THC is decarboxylated, making the product orally active without further heating. THC distillate acts as a partial agonist at the Cannabinoid Receptor 1 (CB1), primarily located in the central nervous system, and the Cannabinoid Receptor 2 (CB2), found largely in the immune system. It is utilized for its potent analgesic, antiemetic, and appetite-stimulating properties. While not a single FDA-approved pharmaceutical product like Marinol (dronabinol), THC distillate is a standardized ingredient used in various medical and recreational cannabis products in legal jurisdictions.

Brand names
The Clear
Other names
THC distillatecannabis distillatedistilled cannabis oil
02

Targets

CNR1 (Cannabinoid receptor 1)

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