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Drug intelligence / Profile preview
tetrahydrocannabinolic acid
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Inhalation, Oral, Sublingual, Buccal, Rectal, Topical, Transdermal, Intravenous, Intranasal, Ophthalmic
01
Overview
Tetrahydrocannabinolic acid (THCA) is a non-psychoactive cannabinoid and the acidic precursor to tetrahydrocannabinol (THC), found abundantly in raw and live cannabis plants. It converts to THC through a process called decarboxylation, typically induced by heat. THCA is being investigated for potential therapeutic properties, including anti-inflammatory, neuroprotective, and antiemetic effects, without producing the intoxicating effects associated with THC.
02
Targets
Anandamide reuptake transporterCNR1 (Cannabinoid receptor 1)CNR2 (Cannabinoid receptor type 2)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)DAGLA (Diacylglycerol lipase alpha)FAAHMGL (Methionine gamma-lyase)NAAA (N-acylethanolamine-hydrolyzing acid amidase)PC-PLC (Phosphatidylcholine-specific phospholipase C)TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPV2 (Transient receptor potential cation channel subfamily V member 2)TRPV3 (Transient receptor potential vanilloid subtype 3)TRPV4 (Transient receptor potential cation channel subfamily V member 4)
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