tetrahydrodeoxyuridine

Tetrahydrodeoxyuridine is a synthetic pyrimidine nucleoside analogue. It is designed to inhibit cytidine deaminase, an enzyme involved in nucleotide metabolism. By inhibiting this enzyme, tetrahydrodeoxyuridine prevents the deamination of cytidine and 2'-deoxycytidine, thereby modulating the metabolism of nucleosides and enhancing the efficacy of certain chemotherapeutic agents that are susceptible to degradation by cytidine deaminase. This mechanism can increase the effectiveness of drugs such as cytarabine or gemcitabine by prolonging their half-life and activity in vivo[2]. The compound has been investigated primarily as a biomodulator in oncology settings.