tetrahydrohyperforin

Tetrahydrohyperforin (IDN 5706) is a **semi-synthetic derivative of hyperforin**, the major active compound from *Hypericum perforatum* (St. John’s Wort). It is designed for **greater stability and oral bioavailability** than hyperforin. IDN 5706 shows **neuroprotective and anti-amyloidogenic properties** and has been investigated primarily as a potential therapeutic for Alzheimer’s disease. Its mechanisms include **inhibiting amyloid-β (Aβ) aggregation**, promoting disaggregation of pre-formed Aβ fibrils, decoupling acetylcholinesterase (AChE) from Aβ (reducing AChE–Aβ complex neurotoxicity), decreasing tau hyperphosphorylation, and likely inhibiting γ-secretase-dependent cleavage of amyloid precursor protein (APP) leading to reduced Aβ formation. It also reduces neuroinflammation and prevents synaptic protein loss in animal models[1][2][5].

Other names

IDN 5706IDN5706IDN-5706tetrahydrohyperforin