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Tetrase
- Development stage
- Unknown
- Lead developer
- Metagenics
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Tetrase is a proprietary botanical extract developed by Metagenics, Inc., derived from hops (*Humulus lupulus L.*). Its primary active components are tetrahydro-iso-alpha acids (THIAA). Tetrase is characterized as a selective kinase response modifier (SKRM), meaning it modulates specific kinase signaling pathways involved in the inflammatory response, such as those regulating prostaglandin E2 (PGE2) production. Unlike non-selective COX inhibitors, it is designed to provide anti-inflammatory benefits with a reduced risk of gastrointestinal side effects. It is primarily used as a key ingredient in nutraceutical formulations, such as Kaprex, aimed at relieving joint pain and minor inflammation. Metagenics holds patents for Tetrase as an all-natural anti-inflammatory agent.
- Brand names
- Tetrase
- Other names
- tetrahydro-iso-alpha acidsTHIAAtetrahydro-iso-alpha acids complex
02
Targets
PPARA (Peroxisome proliferator-activated receptor alpha)RXRA (Retinoid X receptor alpha)
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