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TfRMAb-TNFR
- Development stage
- Preclinical
- Lead developer
- Chapman University
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intraperitoneal, Subcutaneous
01
Overview
**TfRMAb-TNFR** is an investigational brain-penetrant recombinant fusion protein developed in academic research at Chapman University for neurodegenerative disease. It fuses a mouse transferrin receptor antibody transport domain to the extracellular domain of the type II human tumor necrosis factor alpha receptor, creating a soluble TNF-alpha decoy receptor that is transported across the blood-brain barrier through transferrin receptor-mediated transcytosis. In transgenic mouse models of Alzheimer’s disease and tauopathy, chronic dosing reduced neuroinflammatory and pathological markers, including microgliosis, amyloid-beta pathology, and tau phosphorylation, with evidence of improved memory-related outcomes in APP/PS1 mice. ([mdpi.com](https://www.mdpi.com/1999-4923/14/10/2200))
- Other names
- TfRMAb + TNFR
02
Targets
TFRC (Transferrin Receptor)TNFA (Tumor necrosis factor alpha (soluble))
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