TFV IVR

The TFV IVR (Tenofovir Intravaginal Ring) is a drug delivery device designed for HIV prevention in women. It's a reservoir-type polyurethane intravaginal ring that releases tenofovir, an antiretroviral medication, directly to vaginal tissues. TFV IVR is a reservoir-type intravaginal ring designed to deliver tenofovir (TFV) for HIV prevention. The device consists of thermoplastic polyurethane (TPU) tubing filled with tenofovir, engineered to provide sustained release of the drug to vaginal tissues. This approach allows for near-constant mucosal antiretroviral concentrations without requiring frequent dosing, potentially improving adherence compared to other formulations like gels[1][3]. Clinical trials have shown that the TFV IVR is safe, well-tolerated, and capable of delivering mucosal tenofovir concentrations that exceed those associated with HIV protection[1]. The device has demonstrated zero-order release of tenofovir in vitro for up to 90 days, suggesting potential for long-term use with infrequent replacement[3]. A key advantage of this delivery system is reduced systemic side effects compared to oral administration while maintaining effective local drug concentrations. Animal studies in sheep and macaques have shown promising results, with the TFV IVR providing elevated vaginal drug concentrations and protection against viral challenges[3].

Other names

Tenofovir Intravaginal Ring