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TGRX-3544
- Development stage
- Preclinical
- Lead developer
- Shenzhen TargetRx
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules
01
Overview
TGRX-3544: sourced facts only. name: "TGRX-3544 is a heterobifunctional degrader which promotes ubiquitination and proteasomal degradation of oncogenic KIT." [DOI:10.1158/1538-7445.am2025-1656]; target: "TGRX-3544 is a heterobifunctional degrader which promotes ubiquitination and proteasomal degradation of oncogenic KIT." [DOI:10.1158/1538-7445.am2025-1656]; developer: "Shenzhen TargetRx, Inc., Shenzhen, China." [DOI:10.1158/1538-7445.am2025-1656]; modality: "TGRX-3544 is a heterobifunctional degrader which promotes ubiquitination and proteasomal degradation of oncogenic KIT." [DOI:10.1158/1538-7445.am2025-1656]; stage: "In vivo, TGRX-3544 led to dose-dependent tumor regression in xenograft models expressing E11 or E11/E17 mutant KIT." [DOI:10.1158/1538-7445.am2025-1656]
02
Targets
KIT (c-KIT proto-oncogene receptor tyrosine kinase)
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