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Drug intelligence / Profile preview
TGRX-3911
- Development stage
- Preclinical
- Lead developer
- Shenzhen TargetRx
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules
01
Overview
TGRX-3911: sourced facts only. name: "TGRX-3911 is a heterobifunctional molecule that promotes ubiquitination and proteasomal degradation of BTK." [DOI:10.1158/1538-7445.am2025-5619]; target: "TGRX-3911 is a heterobifunctional molecule that promotes ubiquitination and proteasomal degradation of BTK." [DOI:10.1158/1538-7445.am2025-5619]; developer: "Shenzhen TargetRx, Inc., Shenzhen, China." [DOI:10.1158/1538-7445.am2025-5619]; modality: "TGRX-3911 is a heterobifunctional molecule that promotes ubiquitination and proteasomal degradation of BTK." [DOI:10.1158/1538-7445.am2025-5619]; stage: "In vivo, oral dosing of TGRX-3911 led to tumor shrinkage in a mantle cell lymphoma (MCL) REC-1 xenograft model expressing BTK-C481S, and the effect was superior to pirtobrutinib." [DOI:10.1158/1538-7445.am2025-5619]
02
Targets
BTK (Bruton tyrosine kinase)
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