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thalidomide + nab-paclitaxel + gemcitabine + epirubicin

Development stage: Unknown
Lead developer: Grünenthal
Modality: Small Molecules
Administration: Oral, Intravenous

Overview

A combination of four anticancer agents with different mechanisms of action. Thalidomide is an immunomodulatory drug with anti-angiogenic properties and NF-κB inhibition. Nab-paclitaxel (Abraxane) is a taxane that stabilizes microtubules and prevents cell division. Gemcitabine is a nucleoside analog that interferes with DNA synthesis. Epirubicin is an anthracycline topoisomerase II inhibitor that interferes with DNA and RNA synthesis.

Targets

TUBB (Tubulin (alpha and beta subunits))CDA (Cytidine deaminase)CRBN (Cereblon)TOP2A (DNA topoisomerase II)DNA

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